National museum of Taplica was founded in 1946 in Prokuplje. The museum has archaeological collection, collections dedicated to Toplica uprising of 1917, collections dedicated to NOB during the Second World War, a room with ethnological material and two galleries. One of two galleries is within the museum, and another one is a separate object. The building in which the museum is located was built in 1925, and represents protected cultural monument.

In recent years several archaeological types of research have been implemented by the jurisdiction of the museum at several places of Toplica County. Various cultural events organized in the museum building attract visitors.